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Comparison of automated erythrocytapheresis versus manual exchange transfusion to treat cerebral macrovasculopathy in sickle cell anemia

Authors :
Pauline Voultoury
Hendy Abdoul
Laurent Holvoet
Nathalie Couque
Florence Missud
Suzanne Verlhac
André Baruchel
Julie Sommet
Berengere Koehl
Fatiha Sellami
Ghislaine Ithier
Malika Benkerrou
Priscilla Boizeau
Source :
Transfusion. 56:1121-1128
Publication Year :
2016
Publisher :
Wiley, 2016.

Abstract

BACKGROUND Chronic exchange transfusion is effective for primary and secondary prevention of stroke in children with sickle cell anemia (SCA). Erythrocytapheresis is recognized to be the most efficient approach; however, it is not widely implemented and is not suitable for all patients. The aim of our study was to compare automated exchange transfusion (AET) with our manual method of exchange transfusion and, in particular, to evaluate the efficacy, safety, and cost of our manual method. STUDY DESIGN AND METHODS Thirty-nine SCA children with stroke and/or abnormal findings on transcranial Doppler were included in the study. We retrospectively analyzed 1353 exchange sessions, including 333 sessions of AET and 1020 sessions of manual exchange transfusion (MET). RESULTS Both methods were well tolerated. The median decrease in hemoglobin (Hb)S per session was 21.5% with AET and 18.8% with our manual method (p

Details

ISSN :
00411132
Volume :
56
Database :
OpenAIRE
Journal :
Transfusion
Accession number :
edsair.doi...........ba17a290c7e1767e9f340fbb53e9245e
Full Text :
https://doi.org/10.1111/trf.13548