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Comparison of automated erythrocytapheresis versus manual exchange transfusion to treat cerebral macrovasculopathy in sickle cell anemia
- Source :
- Transfusion. 56:1121-1128
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- BACKGROUND Chronic exchange transfusion is effective for primary and secondary prevention of stroke in children with sickle cell anemia (SCA). Erythrocytapheresis is recognized to be the most efficient approach; however, it is not widely implemented and is not suitable for all patients. The aim of our study was to compare automated exchange transfusion (AET) with our manual method of exchange transfusion and, in particular, to evaluate the efficacy, safety, and cost of our manual method. STUDY DESIGN AND METHODS Thirty-nine SCA children with stroke and/or abnormal findings on transcranial Doppler were included in the study. We retrospectively analyzed 1353 exchange sessions, including 333 sessions of AET and 1020 sessions of manual exchange transfusion (MET). RESULTS Both methods were well tolerated. The median decrease in hemoglobin (Hb)S per session was 21.5% with AET and 18.8% with our manual method (p
- Subjects :
- Erythrocytapheresis
Pediatrics
medicine.medical_specialty
Anemia
business.industry
medicine.medical_treatment
Immunology
Exchange transfusion
Retrospective cohort study
Hematology
030204 cardiovascular system & hematology
medicine.disease
Sickle cell anemia
Transcranial Doppler
03 medical and health sciences
0302 clinical medicine
Interquartile range
medicine
Immunology and Allergy
business
Stroke
030215 immunology
Subjects
Details
- ISSN :
- 00411132
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Transfusion
- Accession number :
- edsair.doi...........ba17a290c7e1767e9f340fbb53e9245e
- Full Text :
- https://doi.org/10.1111/trf.13548