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Mortality in major affective disorder: relationship to subtype of depression
- Source :
- Acta Psychiatrica Scandinavica. 87:329-335
- Publication Year :
- 1993
- Publisher :
- Wiley, 1993.
-
Abstract
- A total of 219 inpatients with a DSM-III diagnosis of major depression, 150 women and 69 men, were followed prospectively for 3-10 years and mortality was recorded. The patients were previous participants in psychopharmacological multicenter trials, which were carried out for the purpose of comparing the antidepressant effect of newer 5-HT reuptake inhibitors with that of the tricyclic antidepressant drug, clomipramine. The study comprised patients with a total Hamilton Rating Scale for Depression score of > or = 18 and/or a Hamilton subscale score of > or = 9. Diagnostic classification according to the Newcastle I Scale in endogenous and nonendogenous depression was performed. The observed mortality was significantly greater than that expected. The increased mortality was essentially due to suicides and mainly found among women. Patients scored as nonendogenously depressed had a significantly higher suicide rate than endogenously depressed patients. The excess number of suicides in the nonendogenous group largely occurred within the first year of observation. No association was found between response to the antidepressant treatment in the trial and the suicide risk in the first 3 years of observation. Language: en
- Subjects :
- Clomipramine
medicine.medical_specialty
business.industry
medicine.drug_class
Poison control
Tricyclic antidepressant
Hamilton Rating Scale for Depression
Psychiatry and Mental health
Internal medicine
Epidemiology
Medicine
Antidepressant
Risk factor
business
Psychiatry
Depression (differential diagnoses)
medicine.drug
Subjects
Details
- ISSN :
- 16000447 and 0001690X
- Volume :
- 87
- Database :
- OpenAIRE
- Journal :
- Acta Psychiatrica Scandinavica
- Accession number :
- edsair.doi...........ba22b52eacf638d2d5ae49ef5884e7ef
- Full Text :
- https://doi.org/10.1111/j.1600-0447.1993.tb03381.x