Plakortethers A−G: A New Class of Cytotoxic Plakortin−Derived Metabolites

Authors :: Orazio Taglialatela-Scafati
Barbara Pisano
Angela Ianaro
Claudio Campagnuolo
Ernesto Fattorusso
Source :: European Journal of Organic Chemistry. 2002:61-69
Publication Year :: 2002
Publisher :: Wiley, 2002.
Abstract: Plakortethers A−G (4−10) represent a new class of plakortin-related metabolites containing a trisubstituted tetrahydrofuran ring. They have been isolated from the Caribbean sponge Plakortis simplex and their stereostructures fully characterized by a combination of spectroscopic data and chemical evidence, based on a three-step conversion of the cycloperoxide plakortin into plakortether B (5). Plakortethers A (4), B (5), D (7), and E (8) exhibited selective cytotoxicity against the RAW 264-7 cell line (murine macrophage).

Subjects :: Plakortis simplex
chemistry.chemical_compound
Sponge
chemistry
biology
Cell culture
Stereochemistry
Organic Chemistry
Cytotoxic T cell
Physical and Theoretical Chemistry
Selective cytotoxicity
biology.organism_classification
Tetrahydrofuran

ISSN :: 10990690 and 1434193X
Volume :: 2002
Database :: OpenAIRE
Journal :: European Journal of Organic Chemistry
Accession number :: edsair.doi...........ba8744bd44f6d9b6ac29018398547c75
Full Text :: https://doi.org/10.1002/1099-0690(20021)2002:1<61::aid-ejoc61>3.0.co;2-e