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A Series of 7-ω-carboxamidoalkyl-substituted estra-1,3,5(10),6-tetraenes

Authors :
Masao Imai
Thies Thiemann
Kuniharu Umeno
Eiko Inohae
Shuntaro Mataka
Yuji Shima
Source :
Journal of Chemical Research. 2002:1-3
Publication Year :
2002
Publisher :
SAGE Publications, 2002.

Abstract

A number of 7-ω-carboxamidoalkyl-substituted estra-1,3,5(10),6-tetraenes as potential ligands for the estrogen receptor ERα have been prepared using either a conjugate addition of α,ω-iodoalkanenitriles or a Michael addition to steroidal ketone 3 as the key step.

Details

ISSN :
20476507 and 17475198
Volume :
2002
Database :
OpenAIRE
Journal :
Journal of Chemical Research
Accession number :
edsair.doi...........baabafca407474a4924824bd41535d9b
Full Text :
https://doi.org/10.3184/030823402103170312