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The B-cell-activating factor signalling pathway is associated withHelicobacter pyloriindependence in gastric mucosa-associated lymphoid tissue lymphoma without t(11;18)(q21;q21)
- Source :
- The Journal of Pathology. 241:420-433
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- We previously reported that activation of the B cell-activating factor (BAFF) pathway upregulates NF-κB and induces BCL3 and BCL10 nuclear translocation in H. pylori (HP)-independent gastric diffuse large B-cell lymphoma (DLBCL) tumours with evidence of mucosa-associated lymphoid tissue (DLBCL [MALT]). However, the significance of BAFF expression in HP-independence of gastric low-grade MALT lymphomas (MALT lymphoma) without t(11;18)(q21;q21) remains unexplored. Sixty-four patients who underwent successful HP eradication for localized HP-positive gastric MALT lymphomas without t(11;18)(q21;q21) were studied. BAFF expression was significantly higher in the HP-independent group than in the HP-dependent group (22 of 26 [84.6%] versus 8 of 38 [21.1%]; p
- Subjects :
- 0301 basic medicine
MALT lymphoma
NF-κB
Biology
medicine.disease
BCL10
Pathology and Forensic Medicine
Lymphoma
03 medical and health sciences
chemistry.chemical_compound
Transactivation
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
chemistry
immune system diseases
hemic and lymphatic diseases
030220 oncology & carcinogenesis
Immunology
Cancer research
medicine
Gastric mucosa
B-cell activating factor
Autocrine signalling
Subjects
Details
- ISSN :
- 00223417
- Volume :
- 241
- Database :
- OpenAIRE
- Journal :
- The Journal of Pathology
- Accession number :
- edsair.doi...........bab7957d1e5cc79795a5e10b7faf7440