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Synthesis, crystal structure, DNA binding and in vitro cytotoxicity studies of Zn(II) complexes derived from amino-alcohol Schiff-bases
- Source :
- Inorganica Chimica Acta. 482:136-143
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Three new zinc(II) complexes, namely, [Zn2(H2L1)2(OAc)2] (1), [Zn3(H2L1)2(OAc)4] (2) and {[Zn3(H2L2)2(OAc)4]·C2H5OH·DMF} (3) [(H3L1 = Schiff-base derived from salicylaldehyde and 2-amino-2-ethyl-1,3-propanediol and H3L2 = Schiff-base derived from 5-chlorosalicylaldehyde and 2-amino-2-ethyl-1,3-propanediol)], were synthesized and characterized using elemental analyses, infrared spectroscopy and X-ray diffraction. Single crystal structure analysis reveals that complex 1 is five-coordinated distorted square pyramidal configuration. Complexes 2 and 3 exhibit the similar trinuclear structure. And the alkoxy groups in the ligands are play an important role in the formation of supramolecular networks of complexes 1–3. The interaction of the complexes 1–3 with calf thymus (CT) DNA was investigated using UV–visible (UV–Vis), circular dichroism spectra (CD), fluorescence, viscosity and thermal denaturation methods. The intrinsic binding constants for the complexes are found to order of 104 indicating that the complexes are good metallo-intercalators. Complex 1 shows maximum binding affinity (Kb: 7.64 × 104) compared to others. The all complexes can bind to CT-DNA via intercalative mode. The MTT assay show that the cytotoxicity of dinuclear complex 1 is more effective with HeLa cancerous cells. All the experimental results are suggestive that the nuclearity and configuration of zinc complexes have significant influence on their properties.
- Subjects :
- 010405 organic chemistry
Chemistry
Supramolecular chemistry
Infrared spectroscopy
chemistry.chemical_element
Zinc
Crystal structure
010402 general chemistry
01 natural sciences
Square pyramidal molecular geometry
0104 chemical sciences
Inorganic Chemistry
chemistry.chemical_compound
Crystallography
Salicylaldehyde
Materials Chemistry
Alkoxy group
Physical and Theoretical Chemistry
Single crystal
Subjects
Details
- ISSN :
- 00201693
- Volume :
- 482
- Database :
- OpenAIRE
- Journal :
- Inorganica Chimica Acta
- Accession number :
- edsair.doi...........bb923fa67f394e0c7e36adceabdde672