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Polymorphism of the porcine miR-30d is associated with adipose tissue accumulation, its fatty acid profile and the ME1 gene expression
- Source :
- Livestock Science. 182:54-57
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- The miR-30 gene family includes potential regulators of adipogenesis. We searched for polymorphism in this gene family in 4 pig breeds: Duroc, Pietrain, Polish Landrace (PL), Polish Large White (PLW) and a synthetic line (L990). Altogether 5 single nucleotide polymorphisms (SNPs) in 3 genes were found, including one already known SNP rs340704946 within the pre-miR-30d genomic sequence. An association of the rs340704946 with intramuscular fat (IMF) content, abdominal fat accumulation and daily body mass gain in L990 was found. Moreover, the AG genotype was associated with an increased content of monounsaturated fatty acids (MUFA) in subcutaneous (P=0.027) and visceral fat (P=0.007) tissues when compared to the GG genotype. Analysis of PLW pigs revealed an association of the rs340704946 with transcript level of the ME1 gene in longissimus dorsi (LD) muscle (P=0.002), as well as the ME1 protein product in the LD muscle (P
- Subjects :
- Genetics
chemistry.chemical_classification
medicine.medical_specialty
General Veterinary
Adipose tissue
Fatty acid
Single-nucleotide polymorphism
Biology
Endocrinology
chemistry
Adipogenesis
Internal medicine
Gene expression
Genotype
medicine
Gene family
Animal Science and Zoology
Intramuscular fat
Subjects
Details
- ISSN :
- 18711413 and 34070494
- Volume :
- 182
- Database :
- OpenAIRE
- Journal :
- Livestock Science
- Accession number :
- edsair.doi...........bc8a4562cda5d1dd45be2892886d8a9b