Phase 1/2a study of once daily oral BAL101553, a novel tumor checkpoint controller (TCC), in adult patients with advanced solid tumors

Authors :: Stephanie Anderson
Donna Crawford
Caterina Aversa
Michael-John Devlin
Alison L. Hannah
Rebecca Kristeleit
Heidi Lane
T.R. Jeffry Evans
Phil McKernan
Felix Bachmann
R. Rulach
Elizabeth Ruth Plummer
Patrice Larger
Marc Engelhardt
Manolo D'Arcangelo
Juanita Lopez
Noor Md Haris
Alvaro Henrique Ingles Garces
Rowan Miller
Thomas Kaindl
Source :: Journal of Clinical Oncology. 36:2530-2530
Publication Year :: 2018
Publisher :: American Society of Clinical Oncology (ASCO), 2018.
Abstract: 2530Background: BAL101553 is the prodrug of BAL27862, a small molecule TCC that binds microtubules and promotes tumor cell death by activation of the spindle assembly checkpoint. In a study of BAL1...

Subjects :: Cancer Research
Adult patients
business.industry
Prodrug
Small molecule
Spindle checkpoint
Oncology
Microtubule
Control theory
Tumor cell death
Cancer research
Medicine
Once daily
business

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