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Does migrative and proliferative capability of epithelial cells reflect cellular developmental competence?

Authors :
Michal Jeseta
Sylwia Borys
Paweł Antosik
Michał Nowicki
Bartosz Kempisty
Maurycy Jankowski
Yan Huang
Wiesława Kranc
Marta Dyszkiewicz-Konwińska
Małgorzata Bruska
M. Machatkova
Dorota Bukowska
Magdalena Magas
Artur Bryja
Joanna Budna
Sandra Knap
Klaus P. Brüssow
Maciej Zabel
Source :
Medical Journal of Cell Biology. 6:1-7
Publication Year :
2018
Publisher :
Walter de Gruyter GmbH, 2018.

Abstract

Mammalian epithelial and epithelial-like cells are significantly involved in various processes associated with tissue development, differentiation and oncogenesis. Because of that, high number of research is focused on identifying cells that express stem-like or progenitor characteristics. Identifying such cells and recognizing their specific markers, would open new clinical opportunities in transplantology and oncology. There are several epithelia characterized by their ability to rapidly proliferate and/or differentiate. Due to their function or location they are subject to cyclic changes involving processes of apoptosis and regeneration. Literature presenting well-structured studies of these types of epithelia was analyzed in order to compare various results and establish if epithelial cells’ migrative and proliferative ability indicates their stemness potential. Endometrial, ovarian, oviductal and oral mucosal epithelia were analyzed with most of the publications delivering relatively unified results. The ability to rapidly proliferate/differentiate usually indicated the presence of some kind of stem/stem-like/progenitor cells. Most of the papers focused on pinpointing the exact location of these kind of cells, or analyzing specific markers that would be used for their future identification. There have also been substantial proportion of research that focused on discovering growth factors or intercellular signals that induced proliferation/differentiation in analyzed epithelia. Most of the research provided valuable insights into the modes of function and characteristics of the analyzed tissue, outlining the importance of such study for the possible clinical application of in vitro derived cell cultures.

Details

ISSN :
25443577
Volume :
6
Database :
OpenAIRE
Journal :
Medical Journal of Cell Biology
Accession number :
edsair.doi...........bcdd0ccb4070294cfba6ac9abfceb6ea
Full Text :
https://doi.org/10.2478/acb-2018-0001