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EFFECT OF HEXANE FRACTION FROM PAPAYA (CARICA PAPAYA L.) MALE FLOWER ON CELL CYCLE OF COLON ADENOCARCINOMA (WIDR) CELL AND ITS COMBINATION INDEX WITH DOXORUBICIN
- Source :
- Asian Journal of Pharmaceutical and Clinical Research. 11:138
- Publication Year :
- 2018
- Publisher :
- Innovare Academic Sciences Pvt Ltd, 2018.
-
Abstract
- Objective: This study aimed to evaluate the effects of papaya (Carica papaya L.) male flower hexane fraction (PHF) on cell cycle of colon adenocarcinoma (WiDr) cell and its combination index (CI) with doxorubicin.Methods: Flow cytometer and the CI were used to show the PHF on cell cycle of colon adenocarcinoma (WiDr) cell and to calculate the synergism potential, respectively.Result: The result showed that the PHF giving inhibition on cell cycle of colon adenocarcinoma (WiDr) cell in G0-G1, S, G2-M phase. Furthermore, the combination of PHF with doxorubicin in colon adenocarcinoma (WiDr) cell gave a strong synergistic effect with optimal concentration of 8 μg/ml–50 nM (PHF-Doxorubicin) with the IC score lower than 1.Conclusion: This study provides evidence that PHF could be a new potential co-chemotherapeutic agent with doxorubicin on colon adenocarcinoma cell.
- Subjects :
- Pharmacology
biology
Chemistry
Cell
Pharmaceutical Science
Combination index
Fraction (chemistry)
Cell cycle
biology.organism_classification
Molecular biology
digestive system diseases
Hexane
chemistry.chemical_compound
medicine.anatomical_structure
mental disorders
medicine
Pharmacology (medical)
Doxorubicin
Colon adenocarcinoma
Carica
medicine.drug
Subjects
Details
- ISSN :
- 24553891 and 09742441
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Asian Journal of Pharmaceutical and Clinical Research
- Accession number :
- edsair.doi...........bcef0134140b082f5e30c41b94dc1f75