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Prognosticating survival of pineal parenchymal tumors of intermediate differentiation (PPTID) by grade

Authors :
Michael E. Ivan
Alexis Morell
Ricardo J. Komotar
Evan Luther
Victor M. Lu
Daniel G Eichberg
Ashish H. Shah
Source :
Journal of Neuro-Oncology. 155:165-172
Publication Year :
2021
Publisher :
Springer Science and Business Media LLC, 2021.

Abstract

Pineal parenchymal tumors of intermediate differentiation (PPTID) are a rare group of pineal parenchymal tumors classified by histology as either World Health Organization (WHO) Grades 2 or 3. The rarity of these tumors in adults has left a number of clinical management questions open. Correspondingly, the aim of this study was to aggregate a large PPTID cohort with sufficient statistical power from a large national cancer database to analyze prognostic parameters. All PPTID patients aged over 18 years in the U.S. National Cancer Database (NCDB) between 2005 and 2016 were retrospectively reviewed. Data were summarized and survival was modeled using Kaplan–Meier and Cox regression analyses. A total of 103 adult PPTID patients were identified in the NCDB with 63 (61%) WHO Grade 2 and 40 (39%) WHO Grade 3 tumors. Overall, mean age was 53 ± 18 years with even gender distribution. A total of 75 (73%) patients underwent surgical resection for diagnosis, with gross total resection (GTR) was the most common resection outcome in 50/75 (67%). Chemotherapy was utilized in 18 (17%) patients, and radiation therapy in 37 (36%) patients. Overall, 5-year survival rate was estimated to be 54% (95% CI 42–64%), with mean survival was 84 (95% CI 69–99) months. Patients with Grade 2 tumors survived statistically longer than Grade 3 tumor counterparts (P

Details

ISSN :
15737373 and 0167594X
Volume :
155
Database :
OpenAIRE
Journal :
Journal of Neuro-Oncology
Accession number :
edsair.doi...........bd22c92d2b3a968ac54ecd86755e946b
Full Text :
https://doi.org/10.1007/s11060-021-03863-y