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Evidence for Eicosanoids Within the Reparative Front in Avascular Necrosis of Human Femoral Head
- Source :
- Clinical Orthopaedics and Related Research. 281:305
- Publication Year :
- 1992
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1992.
-
Abstract
- Eicosanoids, including prostaglandins and leukotrienes, are important mediators of inflammation. To observe inflammation after necrosis, the histology and the changes of eicosanoid levels were compared in the subchondral cortex and spongy bone of femoral head of sixteen patients with Ficat III or IV idiopathic avascular necrosis (AVN). Neither inflammatory cells nor elevation of eicosanoid levels were observed in the necrotic subchondral cortex or osteochondral junction, whereas infiltration of lymphocytes and plasma cells, fibrosis, and fat emboli were present in the reparative front of necrotic spongy bone. Biochemical analysis in this region revealed significant increases of prostaglandin E2 (PGE2), 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), thromboxane B2 (TXB2), leukotriene B4 (LTB4), and LTC4. The increased eicosanoids due to initial necrosis become aggravating factors by increasing vascular permeability, which leads to marrow edema and intraosseous hypertension; it ultimately develops into a cycle of inflammation and AVN.
- Subjects :
- Idiopathic avascular necrosis
Pathology
medicine.medical_specialty
Necrosis
Aseptic necrosis
business.industry
Prostaglandin
Inflammation
Avascular necrosis
General Medicine
respiratory system
medicine.disease
Femoral head
chemistry.chemical_compound
medicine.anatomical_structure
Eicosanoid
chemistry
Medicine
lipids (amino acids, peptides, and proteins)
Orthopedics and Sports Medicine
Surgery
medicine.symptom
business
Subjects
Details
- ISSN :
- 0009921X
- Volume :
- 281
- Database :
- OpenAIRE
- Journal :
- Clinical Orthopaedics and Related Research
- Accession number :
- edsair.doi...........bd4596df38da857ead7895423a429f38