Synthesis and antimicrobial activity of 3-aroyl-4-heteroaryl pyrroles and pyrazoles

A variety of bis heterocycles-heteroaryl pyrazoles (5) and pyrroles (6) were prepared from heteroaryl chalcones adopting 1,3-dipolar cycloaddition reaction and studied their antimicrobial activity. The compounds 5d and 5f having bromo and nitro substituents on the aromatic ring are the potent antimicrobial agents against Bacillus subtilis and Aspergillus niger.