Synthesis and DNA-binding Properties of Trehalose-tethered Monomeric and Dimeric Berberines

E-mail: whchen@smu.edu.cnReceived November 13, 2012, Accepted December 5, 2012Trehalose-tethered monomeric and dimeric berberines were synthesized in 50% and 30% from the reaction ofberberrubine with 6-tosyl-α,α'-trehalose and 6,6'-ditosyl-α,α'-trehalose, respectively, and fully characterizedby MS (HR and ESI) and NMR (