Nickel-Catalyzed sp3 C–H Bond Activation from Decarboxylative Cross­Coupling of α,β-Unsaturated Carboxylic Acids with Amides

Nickel-catalyzed functionalization of C(sp3)–H bonds adjacent to a nitrogen atom in amides through decarboxylative cross-coupling of α,β-unsaturated carboxylic acids is reported. A possible reaction mechanism is proposed that involves radical intermediate species.