ChemInform Abstract: Modulation of PPAR Subtype Selectivity. Part 2. Transforming PPARα/γ Dual Agonist into α Selective PPAR Agonist Through Bioisosteric Modification

Authors :: Rajesh Bahekar
et al. et al.
Source :: ChemInform. 42
Publication Year :: 2011
Publisher :: Wiley, 2011.
Abstract: Bioisosteric replacement of the rigid oxazole ring of a previously reported PPARα/γ dual agonist with a flexible lipophilic tail leads to a series of oxime containing benzyl dioxanecarboxylic acid derivatives.

Subjects :: chemistry.chemical_classification
Agonist
chemistry.chemical_compound
chemistry
Stereochemistry
medicine.drug_class
medicine
Peroxisome proliferator-activated receptor
Subtype selectivity
General Medicine
Oxime
PPAR agonist
Oxazole

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