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Ag2CO3-catalyzed efficient synthesis of internal or terminal propargylicamines and chalcones via A3-coupling under solvent-free condition
- Source :
- Chinese Chemical Letters. 32:3993-3997
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Several simple, fast and practical protocols have been developed to synthesize internal or terminal propargylamines and chalcones via A3-coupling reaction of aldehydes, amines, and alkynes catalyzed by an easily available catalyst Ag2CO3 under solvent-free condition. The reaction proceeded smoothly to deliver various products in good-to-excellent yields with good functional group tolerance. Gram-scale preparation, bioactive molecule synthesis and asymmetric substrates have been demonstrated. Furthermore, plausible mechanisms for the synthesis of different products have been proposed.
- Subjects :
- Solvent free
02 engineering and technology
General Chemistry
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
Catalysis
Coupling (electronics)
chemistry.chemical_compound
chemistry
Terminal (electronics)
Functional group
Molecule
0210 nano-technology
Subjects
Details
- ISSN :
- 10018417
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Chinese Chemical Letters
- Accession number :
- edsair.doi...........c25bcc5e456e3f744ca41e1759ada054