Assessment of the effect of pharmaceuticals used to treat motion sickness on adaptation to model conditions involving prolonged rotation

The pharmacological preparation P-4 administered according to a reduced scheme (the first dose, 1.5–2 h before stimulation; the second dose, 2 h after stimulation) efficiently alleviated the main symptoms of motion sickness, accelerated the process of adaptation and increased its efficiency in persons prone to motion sickness upon exposure to slow rotation during four days. Administration of the preparation according to the scheme described above did not cause the abstinence syndrome.