Synthesis and antitumor properties of novel 14-β-hydroxytaxol and related analogues

Authors :: John F. Kadow
Vyas M. Dolatrai
Craig Fairchild
C. William Rose
Joydeep Kant
Vittorio Farina
David R. Langley
Byron H. Long
Source :: Bioorganic & Medicinal Chemistry Letters. 4:1565-1570
Publication Year :: 1994
Publisher :: Elsevier BV, 1994.
Abstract: Novel analogues of TAXOL ® with an additional hydroxyl group at the C-14 position were synthesized and evaluated as antitumor agents.

Subjects :: Chemotherapy
Chemistry
Stereochemistry
medicine.medical_treatment
Organic Chemistry
Clinical Biochemistry
Pharmaceutical Science
macromolecular substances
Biochemistry
Chemical synthesis
mental disorders
Drug Discovery
medicine
Molecular Medicine
Molecule
Cytotoxicity
Molecular Biology

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