Pairing and Electrofusion of Liposomes in a Dynamic Microarray Device

In this paper, we present a microfluidic device for electrofusion of liposomes. The device contains hydrodynamic microarray system for pairing liposomes and two microelectrodes for the application of electric field on the paired liposomes. Arraying multiple pairing channels, we demonstrated the electrofusion of paired liposomes in the dynamic microarray structure. We believe this device will become a useful tool for analysis of biochemical reaction inside liposomes and for introducing external substances into cells.