Administration of Immune Globulin Associated With Aseptic Meningitis

To the Editor. —We report herein a case of aseptic meningitis probably caused by administration of immune globulin, which resulted in headache, vomiting, and fever.Report of a Case. —A 2-year-old girl was admitted to the hospital on April 29, 1986, for treatment of acute idiopathic thrombocytopenic purpura. She was treated with 20 mg/d of corticosteroids for four weeks, but no rise in platelet count occurred. After three more days of this therapy, she was given 100 mg/d of hydrocortisone intravenously, followed by 0.4 g/kg/d of immune globulin prepared with polyethylene glycol for five days. Seven days after this therapy, she experienced headache and vomiting. Her temperature rose to 38.5°C and neck stiffness developed. The white blood cell count was 15.6 × 109/L (15 600/mm3), with 0.04 (4%) band forms, 0.64 (64%) segmented neutrophils, 0.27 (27%) lymphocytes, and no eosinophils. Tests for C-reactive protein were negative. The