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Muscle rupture associated with statin use
- Source :
- British Journal of Clinical Pharmacology. 82:473-477
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Aim Statins are used in the treatment of hyperlipidaemia. They are among the most commonly prescribed drugs worldwide. Statins have been linked to musculoskeletal adverse drug reactions. However muscle rupture has not been discussed as an adverse drug reaction to statins so far. The aim of this article is to give an overview of cases of muscle rupture associated with the use of statins. Method We analyzed the cases of muscle rupture associated with the use of statins that were collected by the Netherlands Pharmacovigilance Centre Lareb complemented with the review of cases from the EudraVigilance database. Results Fifteen cases of muscle rupture associated with statin use have been identified in the database of the Netherlands Pharmacovigilance Centre. Overall, there was a plausible temporal association of events in most cases. In addition, the EudraVigilance database contained 165 reports of muscle rupture reported in patients using statins. Muscle rupture was disproportionally associated with statin use in both databases. The reporting odds ratio was 23.4 (95% CI 11.9, 46.0) and 14.6 (95% CI 12.3, 17.2), respectively. Conclusion Data from spontaneous reporting systems suggest that use of statins is associated with muscle rupture. Physicians and patients should be aware that this can occur.
- Subjects :
- Pharmacology
medicine.medical_specialty
business.industry
nutritional and metabolic diseases
Odds ratio
030204 cardiovascular system & hematology
Statin treatment
medicine.disease
Surgery
03 medical and health sciences
0302 clinical medicine
Internal medicine
Spontaneous reporting
Pharmacovigilance
medicine
lipids (amino acids, peptides, and proteins)
Pharmacology (medical)
In patient
cardiovascular diseases
030212 general & internal medicine
Drug reaction
Prescribed drugs
business
Adverse drug reaction
Subjects
Details
- ISSN :
- 03065251
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- British Journal of Clinical Pharmacology
- Accession number :
- edsair.doi...........c39b5963cafe5b582eaf9dfaf5e61143