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First determination of the heart-to-mediastinum ratio using cardiac dual isotope (123I-MIBG/99mTc-tetrofosmin) CZT imaging in patients with heart failure: the ADRECARD study
- Source :
- European Journal of Nuclear Medicine and Molecular Imaging. 42:1912-1919
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Cardiac innervation is assessed using the heart-to-mediastinum ratio (HMR) of metaiodobenzylguanidine (MIBG) on planar imaging using Anger single photon emission computed tomography (A-SPECT). The aim of the study was to determine the HMR of MIBG obtained using a CZT-based camera (D-SPECT; Spectrum Dynamics, Israel) in comparison with that obtained using conventional planar imaging. The ADRECARD study prospectively evaluated 44 patients with heart failure. They underwent planar acquisition using the A-SPECT camera 4 h after 123I-MIBG injection (236.4 ± 39.7 MBq). To localize the heart using D-SPECT, 99mTc-tetrofosmin (753 ± 133 MBq) was administered and dual isotope acquisition was performed using the D-SPECT system. HMR was calculated using both planar A-SPECT imaging and front view D-SPECT cine data. In a phantom study, we estimated a model fitting the A-SPECT and the D-SPECT data that was further applied to correct for differences between the cameras. A total of 44 patients (39 men and 5 women, aged 60 ± 11 years) with ischaemic (31 patients) and nonischaemic (13 patients) cardiomyopathy completed the study. Most patients (28 of 44) were NYHA class II, and the mean left ventricular ejection fraction was 33 ± 7 %. The mean HMR values were 1.34 ± 0.15 and 1.45 ± 0.27 from A-SPECT and D-SPECT, respectively (p
- Subjects :
- medicine.medical_specialty
Planar Imaging
Ejection fraction
medicine.diagnostic_test
business.industry
Cardiomyopathy
Mediastinum
General Medicine
Single-photon emission computed tomography
medicine.disease
Imaging phantom
medicine.anatomical_structure
Heart failure
Dual isotope
medicine
Radiology, Nuclear Medicine and imaging
Radiology
Nuclear medicine
business
Subjects
Details
- ISSN :
- 16197089 and 16197070
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- European Journal of Nuclear Medicine and Molecular Imaging
- Accession number :
- edsair.doi...........c487f313ac0811b3f2fb21078fbd91e1