Cis-platinum-diammino-dichloro (CPDD) in chemotherapy of cancers

Summary We have conducted a phase II trial of Cis -platinum-diammino-dichloro (CPDD), which not only demonstrated its remarkable activity in embryonic carcinoma of the testes, but also in ovarian carcinoma, in epidermoid carcinomas, especially in the head and neck, and in cervix carcinomas. Its toxicity, manifested mainly in digestive and renal tracts, permits its administration to hospitalized patients only. This compound is now investigated in combination therapy for the above mentioned tumors.