Diet and Cimetidine Induce Comparable Changes in Theophylline Metabolism in Normal Subjects K.E. ANDERSON, R.B. MCCLEERY, E.S. VESELL, F.F. VICKERS, A. KAPPAS Hepatology 13:941-946, 1991

This study examines the effects of diet and cimetidine on theophylline metabolism in 12 men. Subjects, all nonsmokers within 15% of their ideal body weight, were 23 to 26 years of age and had no unusual dietary habits. Energy needs were calculated using the Harris-Benedict equation. Subjects were placed either on a high-protein, low-carbohydrate diet (44% of total calories as protein, 35% as carbohydrate, and 21% as fat) or a low-protein, high-carbohydrate diet (10% of total calories as protein, 70% as carbohydrate, and 20% as fat) for 15 days on each diet. The order of the dietary periods was reversed in one half of the subjects, and there was a 24-day washout period between the two dietary periods. Cimetidine (800 mg/d at bedtime) was administered on days 10 to 15 of each dietary period. Aminophylline (3 mg of theophylline base/kg body weight) was administered intravenously as a bolus over 20 to 30 minutes on days 8 and 15 of each dietary period. Blood was withdrawn before and at 1, 2, 4, 6, 8, 12, and ...