ChemInform Abstract: Asymmetric Synthesis of Tetrahydropyridines via an Organocatalytic One-Pot Multicomponent Michael/Aza-Henry/Cyclization Triple Domino Reaction

Authors :: Gerhard Raabe
Pankaj Chauhan
Robert Hahn
Dieter Enders
Marcus Bluemel
Source :: ChemInform. 46
Publication Year :: 2015
Publisher :: Wiley, 2015.
Abstract: A squaramide-catalyzed asymmetric multicomponent Michael/aza-Henry/cyclization triple domino reaction of 1,3-dicarbonyl compounds, β-nitroolefins, and imines to provide potentially bioactive tetrahydropyridines in good yields and excellent enantioselectivities is developed.

Subjects :: Cascade reaction
Chemistry
Organocatalysis
Enantioselective synthesis
General Medicine
Combinatorial chemistry

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