ChemInform Abstract: A Facile Approach to Chiral 1,4-Benzodioxane Toward the Syntheses of Doxazosin, Prosympal, Piperoxan, and Dibozane

Starting from commercially available inexpensive optically active diol (I) the synthesis of optically active 2-hydroxymethyl-1,4-benzodioxane (V) is developed and its use as common precursor in the synthesis of the title compounds doxazosin (XI), prosympal (XIIIa), piperoxan (XIIIb), and dibozane (XV) is demonstrated.