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Dispersible MoS2 Nanosheets Activated TGF-β/Smad Pathway and Perturbed the Metabolome of Human Dermal Fibroblasts
- Source :
- ACS Biomaterials Science & Engineering. 3:3261-3272
- Publication Year :
- 2017
- Publisher :
- American Chemical Society (ACS), 2017.
-
Abstract
- In postgraphene two-dimensional materials (2DMs), MoS2 has attracted increasing attention in the biomedical field due to its excellent physicochemical properties. However, the toxicity and biocompatibility evaluation of MoS2 is not fully addressed. Herein, chitosan functionalized MoS2 (CS-MoS2) nanosheets, which showed perfect dispersibility and stability performances, were synthesized and characterized. We found that CS-MoS2 nanosheets inhibited the viability of human dermal fibroblasts (HDFs) moderately while causing cell membrane instability, ROS generation, and DNA damage in a dosage-dependent manner. CS-MoS2 nanosheets did not induce significant changes in the cell morphologies, but they seemed to impair the cell division of HDFs. CS-MoS2 nanosheets (100 μg/mL) activated EGFR and induced reactive oxygen species, Smad, and IL-1, which in turn led to cell inflammation and apoptosis. Furthermore, HDFs showed cellular stress responses when they were exposed to low concentrations of CS-MoS2 nanosheets (25...
- Subjects :
- 0301 basic medicine
chemistry.chemical_classification
Reactive oxygen species
Materials science
Cell division
DNA damage
Cell
Biomedical Engineering
02 engineering and technology
SMAD
021001 nanoscience & nanotechnology
Cell biology
Biomaterials
Cell membrane
03 medical and health sciences
030104 developmental biology
medicine.anatomical_structure
Biochemistry
chemistry
Apoptosis
medicine
0210 nano-technology
Cytotoxicity
Subjects
Details
- ISSN :
- 23739878
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- ACS Biomaterials Science & Engineering
- Accession number :
- edsair.doi...........c70ccea0fa25db0ee0824457df0a101d