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Process Development and Large-Scale Synthesis of BTK Inhibitor BIIB068
- Source :
- Organic Process Research & Development. 24:1199-1206
- Publication Year :
- 2020
- Publisher :
- American Chemical Society (ACS), 2020.
-
Abstract
- Chemical process development efforts leading to multikilogram production of BIIB068 hemiadipate are discussed. Process optimization resulted in (1) removal of transition metal from the process, (2)...
- Subjects :
- biology
010405 organic chemistry
Process development
Chemistry
Scale (chemistry)
Organic Chemistry
010402 general chemistry
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
Scientific method
biology.protein
Bruton's tyrosine kinase
Process optimization
Physical and Theoretical Chemistry
Subjects
Details
- ISSN :
- 1520586X and 10836160
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Organic Process Research & Development
- Accession number :
- edsair.doi...........c7697bd2139a22f282f464a8ae16c611
- Full Text :
- https://doi.org/10.1021/acs.oprd.0c00087