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AIE-active florescent polymers: The design, synthesis and the cell imaging application
- Source :
- Polymer. 133:151-159
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Fluorescence imaging, especially specific organelle imaging, has become a significant technology to comprehending cell transplantation, migration, division, fusion, and lysis. In this paper, we designed and synthesized a water soluble and fluorescent polymer named as Poly(AA-TPA-d), which was pH-responsive by the fluorescence channel due to the presence of poly acrylic acid as the polymer backbone. The research results demonstrated that Poly(AA-TPA-d) exhibits novel aggregation-induced-emission (AIE) property. Additionally, due to the hydrogen bond formation and C=O···π interactions between methyl acrylate groups, Poly(AA-TPA-d) was of excellent hydrogel formation ability. Moreover, Poly(AA-TPA-d) displayed good bio-compatibility with the living MPC5 cells and highly specific cytoplasm-targeting ability by MTT assay and cell staining experiment respectively.
- Subjects :
- chemistry.chemical_classification
Fluorescence-lifetime imaging microscopy
Lysis
Materials science
Polymers and Plastics
Hydrogen bond
Organic Chemistry
02 engineering and technology
Polymer
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
Fluorescence
0104 chemical sciences
chemistry.chemical_compound
chemistry
Polymer chemistry
Materials Chemistry
Biophysics
MTT assay
0210 nano-technology
Methyl acrylate
Acrylic acid
Subjects
Details
- ISSN :
- 00323861
- Volume :
- 133
- Database :
- OpenAIRE
- Journal :
- Polymer
- Accession number :
- edsair.doi...........c7c6b1da26d0948fc37cb4bd309fba97