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Base catalyzed reaction of 1,4-dithiane-2,5-diol with α-oxoketene dithioacetals: a new general method for the synthesis of 2-methylthio-3-aroyl/heteroaroyl thiophenes
- Source :
- Tetrahedron Letters. 57:4302-4305
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- The α-oxoketene dithioacetals and 1,4-dithiane-2,5-diol a dimer of mercapto acetaldehyde, react in the presence of anhydrous potassium carbonate in boiling ethanol to yield the corresponding 2-(methylthio)-3-aroyl/heteroaroyl thiophenes in 55–70% overall yields.
Details
- ISSN :
- 00404039
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........c7edfbb82b1dd5ea2f06666d5fa4288f
- Full Text :
- https://doi.org/10.1016/j.tetlet.2016.08.033