Back to Search
Start Over
Generation of Indoles with Agrochemical Significance through Biotransformation by Chaetomium globosum
- Source :
- Journal of Natural Products. 82:2132-2137
- Publication Year :
- 2019
- Publisher :
- American Chemical Society (ACS), 2019.
-
Abstract
- Six new (1-6) and two known (7 and 8) indole alkaloids were produced by the marine fish-derived fungus Chaetomium globosum 1C51 through biotransformation. The structures of these alkaloids were elucidated by a combination of MS, NMR, and X-ray crystallography analyses. Chaetoindolone A (1) was shown to inhibit the growth of the rice-pathogenic bacteria Xanthomonas oryzae pv. oryzae (xoo) both in vitro and in vivo. Chaetogline A (7) was found to be fungicidal against Sclerotinia sclerotiorum, a pathogen causing rape sclerotinia rot. Collectively, this work provides access to new indole alkaloids with potential agrochemical significance.
- Subjects :
- Pharmacology
Indole test
biology
Chaetomium globosum
010405 organic chemistry
Chemistry
Organic Chemistry
Sclerotinia sclerotiorum
food and beverages
Pharmaceutical Science
Fungus
biology.organism_classification
01 natural sciences
0104 chemical sciences
Analytical Chemistry
Fungicide
010404 medicinal & biomolecular chemistry
Xanthomonas oryzae
Complementary and alternative medicine
Biochemistry
Biotransformation
Drug Discovery
Molecular Medicine
Sclerotinia
Subjects
Details
- ISSN :
- 15206025 and 01633864
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- Journal of Natural Products
- Accession number :
- edsair.doi...........c809cb2bca8bdd9cf87f5a23a44d0f60