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Receptor based design, synthesis and biology of novel somatostatin analogs

Authors :
H. Li
R. H. Mattern
X. Jiang
T. A. Tran
J. Igarashi
M. Goomann
Source :
Peptide Science — Present and Future ISBN: 0792352718
Publication Year :
2006
Publisher :
Kluwer Academic Publishers, 2006.

Abstract

In this approach, we modeled somatostatin receptor-ligand complexes. Based on the information obtained from the structures of the ligand-receptor complexes, we designed and synthesized novel somatostatin analogs with enhanced selectivities.

Subjects

Subjects :
chemistry.chemical_classification
endocrine system
Somatostatin
chemistry
Design synthesis
Stereochemistry
Helical bundle
Receptor
hormones, hormone substitutes, and hormone antagonists
Cyclic peptide

Details

ISBN :
978-0-7923-5271-6
0-7923-5271-8
ISBNs :
9780792352716 and 0792352718
Database :
OpenAIRE
Journal :
Peptide Science — Present and Future ISBN: 0792352718
Accession number :
edsair.doi...........c8a6ca9f2df984180128634a62b75641
Full Text :
https://doi.org/10.1007/0-306-46864-6_115
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