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A case of endocrine mucināproducing sweat gland carcinoma with distant metastasis
- Source :
- Journal of Cutaneous Pathology. 48:937-942
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare cutaneous adnexal neoplasm typically arising on the face of older individuals, most commonly around the eyelids. Histopathologic features include a circumscribed proliferation of low-grade epithelioid cells with areas of cystic and cribriform growth, foci of intracytoplasmic and extracellular mucin, and coexpression of endocrine, neuroendocrine, and cytokeratin markers by immunohistochemistry. Given histopathologic and immunohistochemical similarities, EMPSGC is often likened to solid papillary carcinoma of the breast and endocrine ductal carcinoma in situ, and is thought by many to represent a forme fruste of mucinous carcinoma of the skin. To date, the vast majority of reported cases of EMPSGC have been described as having indolent behavior, with no cases of distant metastasis yet reported. Here we report a unique case of EMPSGC that recurred over several years following standard surgical excision and Mohs micrographic surgery, with subsequent metastasis to the parotid gland and axial skeleton.
- Subjects :
- Pathology
medicine.medical_specialty
Histology
business.industry
Dermatology
Ductal carcinoma
medicine.disease
Pathology and Forensic Medicine
Parotid gland
Metastasis
030207 dermatology & venereal diseases
03 medical and health sciences
Cytokeratin
0302 clinical medicine
medicine.anatomical_structure
030220 oncology & carcinogenesis
Medicine
Endocrine system
Mucinous carcinoma
Immunohistochemistry
business
Epithelioid cell
Subjects
Details
- ISSN :
- 16000560 and 03036987
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Journal of Cutaneous Pathology
- Accession number :
- edsair.doi...........c8b86faedf1448448715e0a6ab59ffd1