ChemInform Abstract: Regioselective Control of the SNAr Amination of 5-Substituted-2,4-dichloropyrimidines Using Tertiary Amine Nucleophiles

The regioselective reaction of 2,4-dichloro-5-nitropyrimidine (I) with tertiary amines (II) and (VI) leads to pyrimidin-2-amines (III) and (VII), resp., whilst the reaction with N-methylpyrrolidine gives rise to unexpected chloride (V).