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Hypoxia and Inflammation-Induced Disruptions of the Blood-Brain and Blood-Cerebrospinal Fluid Barriers Assessed Using a Novel T1-Based MRI Method
- Source :
- Acta Neurochirurgica Supplement ISBN: 9783319184968
- Publication Year :
- 2016
- Publisher :
- Springer International Publishing, 2016.
-
Abstract
- Subtle blood-brain barrier (BBB) disruption is involved in numerous neurological conditions. This disruption is found diffusely in the brain and requires quantitative methods for assessment. We propose a statistical method to identify individual voxels where the BBB is disrupted using T1-weighted MRI. We used models of severe and focal vs. mild and generalized disruption of the BBB to show proof of principle with the cold injury model, hypoxia, and a model of inflammation using low- and high-dose lipopolysaccharide (LPS) treatment. Using voxel-based analysis, we found that mild hypoxia resulted in diffuse disruption of the BBB, whereas more severe hypoxia and high-dose LPS treatment resulted in prominent leakage, particularly in the periventricular area, suggestive of blood-cerebrospinal fluid (CSF) barrier disruption. Our data suggest that the periventricular area may be compromised first in conditions of inflammation and hypoxia. Voxel-based analysis could be used in future studies assessing subtle blood-CSF or BBB disruption.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Lipopolysaccharide
Inflammation
computer.software_genre
Blood–brain barrier
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Cerebrospinal fluid
Voxel
medicine
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
Hypoxia (medical)
030104 developmental biology
medicine.anatomical_structure
nervous system
chemistry
Cold injury
medicine.symptom
business
computer
030217 neurology & neurosurgery
Subjects
Details
- ISBN :
- 978-3-319-18496-8
- ISBNs :
- 9783319184968
- Database :
- OpenAIRE
- Journal :
- Acta Neurochirurgica Supplement ISBN: 9783319184968
- Accession number :
- edsair.doi...........c8d0d46644f69b62a9a98603757b377b