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Dioscin alleviates hashimoto’s thyroiditis by regulating the SUMOylation of IRF4 to promote CD4+CD25+Foxp3+ treg cell differentiation
- Source :
- Autoimmunity. 54:51-59
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- Dioscin has been used as a treatment for Hashimoto’s thyroiditis (HT) in China. However, the molecular mechanisms governing the modes of action of dioscin have not been elucidated. In this study, f...
- Subjects :
- 030203 arthritis & rheumatology
0301 basic medicine
endocrine system
endocrine system diseases
SENP1
Immunology
SUMO protein
FOXP3
Biology
medicine.disease
Treg cell
Thyroiditis
03 medical and health sciences
Cd4 cd25
030104 developmental biology
0302 clinical medicine
medicine
Cancer research
Immunology and Allergy
IRF4
Subjects
Details
- ISSN :
- 1607842X and 08916934
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Autoimmunity
- Accession number :
- edsair.doi...........c9b7e1e391ef7d6fd21ee896d277cedf
- Full Text :
- https://doi.org/10.1080/08916934.2020.1855428