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Synthesis of the AB spiroketal subunit of spongistatin 1 (altohyrtin A): The Pyrone approach

Authors :
Michael T. Crimmins
David G. Washburn
Source :
Tetrahedron Letters. 39:7487-7490
Publication Year :
1998
Publisher :
Elsevier BV, 1998.

Abstract

The synthesis of the AB spiroketal fragment of spongistatin 1 (altohyrtin A) has been accomplished utilizing the addition of a metalated pyrone to an aldehyde followed by acid catalyzed spirocyclization. A stereoselective copper ( I ) promoted conjugate addition of vinylmagnesium bromide was used to establish the C11 stereogenic center.

Details

ISSN :
00404039
Volume :
39
Database :
OpenAIRE
Journal :
Tetrahedron Letters
Accession number :
edsair.doi...........c9b80ab104b84137e9f332efff9a5e43
Full Text :
https://doi.org/10.1016/s0040-4039(98)01629-3