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Synthesis of the AB spiroketal subunit of spongistatin 1 (altohyrtin A): The Pyrone approach
- Source :
- Tetrahedron Letters. 39:7487-7490
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- The synthesis of the AB spiroketal fragment of spongistatin 1 (altohyrtin A) has been accomplished utilizing the addition of a metalated pyrone to an aldehyde followed by acid catalyzed spirocyclization. A stereoselective copper ( I ) promoted conjugate addition of vinylmagnesium bromide was used to establish the C11 stereogenic center.
Details
- ISSN :
- 00404039
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........c9b80ab104b84137e9f332efff9a5e43
- Full Text :
- https://doi.org/10.1016/s0040-4039(98)01629-3