Increased SR Ca cycling contributes to improved contractile performance in SERCA2a-overexpressing transgenic rats

Authors :: Michael Nabauer
Wiebke Horn
Lars S. Maier
Christian Wahl-Schott
Stefan Wagner
Burkert Pieske
Wolfgang-Michael Franz
Stefan Weichert
Nataliya Dybkova
Oliver J. Müller
Christian Pagel
Source :: Cardiovascular Research. 67:636-646
Publication Year :: 2005
Publisher :: Oxford University Press (OUP), 2005.
Abstract: Objective : Heart failure is associated with reduced function of sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a) but increased function of sarcolemmal Na+/Ca2+ exchanger (NCX), leading to decreased SR Ca2+ content and loss of frequency-potentiation of contractile force. We reported that SERCA2a-overexpression in transgenic rat hearts (TG) results in improved contractility. However, it was not clear whether TG have improved contractility due to frequency-dependent improved SR Ca2+ handling. Methods : Therefore, we characterized TG ( n = 35) vs. wild-type (WT) control rats ( n = 39) under physiological conditions (37 °C, stimulation rate

Full Text Access

Tools