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What Is the Point of the Peak? Assessing Steady-State Respiratory Chemoreflex Drive in High Altitude Field Studies
- Source :
- Advances in Experimental Medicine and Biology ISBN: 9783319911366
- Publication Year :
- 2018
- Publisher :
- Springer International Publishing, 2018.
-
Abstract
- Measurements of central and peripheral respiratory chemoreflexes are important in the context of high altitude as indices of ventilatory acclimatization. However, respiratory chemoreflex tests have many caveats in the field, including considerations of safety, portability and consistency. This overview will (a) outline commonly utilized tests of the hypoxic ventilatory response (HVR) in humans, (b) outline the caveats associated with a variety of peak response HVR tests in the laboratory and in high altitude fieldwork contexts, and (c) advance a novel index of steady-state chemoreflex drive (SS-CD) that addresses the many limitations of other chemoreflex tests. The SS-CD takes into account the contribution of central and peripheral respiratory chemoreceptors, and eliminates the need for complex equipment and transient respiratory gas perturbation tests. To quantify the SS-CD, steady-state measurements of the pressure of end-tidal (PET)CO2 (Torr) and peripheral oxygen saturation (SpO2; %) are used to quantify a stimulus index (SI; PETCO2/SpO2). The SS-CD is then calculated by indexing resting ventilation (L/min) against the SI. SS-CD data are subsequently reported from 13 participants during incremental ascent to high altitude (5160 m) in the Nepal Himalaya. The mean SS-CD magnitude increased approximately 96% over 10 days of incremental exposure to hypobaric hypoxia, suggesting that the SS-CD tracks ventilatory acclimatization. This novel SS-CD may have future utility in fieldwork studies assessing ventilatory acclimatization during incremental or prolonged stays at altitude, and may replace the use of complex and potentially confounded transient peak response tests of the HVR in humans.
- Subjects :
- medicine.medical_specialty
Central chemoreceptors
business.industry
Peripheral chemoreceptors
Hypoxic ventilatory response
030204 cardiovascular system & hematology
Effects of high altitude on humans
Peripheral
Peak response
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Cardiology
Ventilatory acclimatization
Respiratory system
business
030217 neurology & neurosurgery
Subjects
Details
- ISBN :
- 978-3-319-91136-6
- ISBNs :
- 9783319911366
- Database :
- OpenAIRE
- Journal :
- Advances in Experimental Medicine and Biology ISBN: 9783319911366
- Accession number :
- edsair.doi...........ca3e3842ed88c4c329f3d9a349f6e7ab