Back to Search
Start Over
Coagulopathy in COVID-19
- Source :
- PULMONOLOGIYA. 30:645-657
- Publication Year :
- 2020
- Publisher :
- Scientific and Practical Reviewed Journal Pulmonology, 2020.
-
Abstract
- Hemostatic disorders play an important role in the pathogenesis and clinical manifestations of COVID-19. The purpose of the research was a detailed consideration of the pathogenesis, clinical manifestations, and methods of diagnosing and treatment of coronavirus-induced coagulopathy (CIC). At the onset of COVID-19, hypercoagulability is detected, and consumption coagulopathy and disseminated intravascular coagulation (DIC) syndrome are usually observed at later stages of the disease. In the pathogenesis of hypercoagulation in patients with COVID-19, proinflammatory cytokines, hyperfibrinogenemia, increased blood levels of von Willebrand factor, factor VIII, neutrophilic extracellular traps, platelet activation, production of antiphospholipid antibodies, microvesicles are of importance. Laboratory findings show increased plasma concentrations of D-dimer, fibrinogen, a longer prothrombin time and a decrease in the number of platelets. The cumulative incidence of thrombotic complications ranges from 21 to 31%. Thrombosis risk factors are intensive care unit stay, leukocytosis, and a high plasma D-dimer concentration. Differential diagnosing of CIC should be carried out with disseminated intravascular coagulation, sepsis-induced coagulopathy, antiphospholipid, hemophagocytic syndromes, thrombotic microangiopathy, and heparin-induced thromocytopenia. CIC may be complicated by sepsis, antiphospholipid syndrome, hemophagocytic syndrome, thrombotic microangiopathy, and heparin-induced thrombocytopenia.The main therapy is low molecular weight heparins treatment. Treatment recommendations are provided.
- Subjects :
- 0301 basic medicine
Pulmonary and Respiratory Medicine
Disseminated intravascular coagulation
medicine.medical_specialty
Thrombotic microangiopathy
biology
business.industry
030204 cardiovascular system & hematology
Fibrinogen
medicine.disease
Gastroenterology
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Von Willebrand factor
Antiphospholipid syndrome
Internal medicine
D-dimer
medicine
biology.protein
Coagulopathy
Platelet activation
business
medicine.drug
Subjects
Details
- ISSN :
- 25419617 and 08690189
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- PULMONOLOGIYA
- Accession number :
- edsair.doi...........ca4e99662de85ddd35de0c5f74df02fc