Reply from the Authors: SGPG in ALS

Reply from the Authors: We thank Dr. Steck et al. for discussing our paper. [1] We agree with them in two essentials: (1) Almost all patients with high titers of antibodies to SGPG also have antibodies to MAG; (2) Almost all patients with high titers of anti-MAG and anti-SGPG have a sensorimotor peripheral neuropathy. [2] They cite as a patient who had a ``motor neuropathy'' (not motor neuron disease) who had two siblings with full-blown ALS. Was that merely a coincidence? Were there really two entirely different and unrelated diseases of the lower motor neuron in the same sibship? Or is that family another reminder that peripheral nerves may be affected in some patients with motor neuron …