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von Willebrand Factor and Management of Heart Valve Disease
- Source :
- Journal of the American College of Cardiology. 73:1078-1088
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- For decades, numerous observations have shown an intimate relationship between von Willebrand factor (VWF) multimer profile and heart valve diseases (HVD). The current knowledge of the unique biophysical properties of VWF helps us to understand the longstanding observations concerning the bleeding complications in patients with severe HVD. Not only does the analysis of the VWF multimer profile provide an excellent evaluation of HVD severity, it is also a strong predictor of clinical events. Also of importance, VWF responds within minutes to any significant change in hemodynamic valve status, making it an accurate marker of the quality of surgical and transcatheter therapeutic interventions. The authors provide in this review a practical, comprehensive, and evidence-based framework of the concept of VWF as a biomarker in HVD, advocating for its implementation into the clinical decision-making process besides usual clinical and imaging evaluation. They also delineate critical knowledge gaps and research priorities to definitely validate this concept.
- Subjects :
- medicine.medical_specialty
biology
Clinical events
business.industry
Point-of-care testing
Disease
030204 cardiovascular system & hematology
3. Good health
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
Von Willebrand factor
hemic and lymphatic diseases
medicine
biology.protein
Biomarker (medicine)
In patient
030212 general & internal medicine
Heart valve
Cardiology and Cardiovascular Medicine
Intensive care medicine
business
Subjects
Details
- ISSN :
- 07351097
- Volume :
- 73
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Cardiology
- Accession number :
- edsair.doi...........cbb540ca61e92caa24c51f9fd6c3bba8
- Full Text :
- https://doi.org/10.1016/j.jacc.2018.12.045