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von Willebrand Factor and Management of Heart Valve Disease

Authors :
Caterina Casari
Annabelle Dupont
Antoine Rauch
Mickael Rosa
Emmanuelle Jeanpierre
Sophie Susen
Basile Verdier
Peter J. Lenting
Camille Paris
Hughes Spillemaeker
Cedric Delhaye
Nicolas Debry
Flavien Vincent
Valentin Loobuyck
André Vincentelli
Eric Van Belle
Source :
Journal of the American College of Cardiology. 73:1078-1088
Publication Year :
2019
Publisher :
Elsevier BV, 2019.

Abstract

For decades, numerous observations have shown an intimate relationship between von Willebrand factor (VWF) multimer profile and heart valve diseases (HVD). The current knowledge of the unique biophysical properties of VWF helps us to understand the longstanding observations concerning the bleeding complications in patients with severe HVD. Not only does the analysis of the VWF multimer profile provide an excellent evaluation of HVD severity, it is also a strong predictor of clinical events. Also of importance, VWF responds within minutes to any significant change in hemodynamic valve status, making it an accurate marker of the quality of surgical and transcatheter therapeutic interventions. The authors provide in this review a practical, comprehensive, and evidence-based framework of the concept of VWF as a biomarker in HVD, advocating for its implementation into the clinical decision-making process besides usual clinical and imaging evaluation. They also delineate critical knowledge gaps and research priorities to definitely validate this concept.

Details

ISSN :
07351097
Volume :
73
Database :
OpenAIRE
Journal :
Journal of the American College of Cardiology
Accession number :
edsair.doi...........cbb540ca61e92caa24c51f9fd6c3bba8
Full Text :
https://doi.org/10.1016/j.jacc.2018.12.045