ChemInform Abstract: Regiospecific Bromination of 2-Phenyl-3H-pyrimidin-4-ones

Three methods for the regiospecific bromination of 2-pnenyl-3H-pyrimidin-4-ones are presented: bromination or the 5-position of the pyrimidine ring, bromination of the 6-benzylic position and simultaneous bromination of both the 5-position of the pyrimidine ring and 6-benzylic position. Reactions were carried out using simple protocols and the brominated pyrimidines were obtained in good yields.