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GENOME REPORT: Chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus)

Authors :
Elizabeth Dong Nguyen
Vahid Nikoonejad Fard
Bernard Y. Kim
Sarah Collins
Miranda Galey
Branden R. Nelson
Paul Wakenight
Simone M. Gable
Aaron McKenna
Theo K. Bammler
Jim MacDonald
Daryl M. Okamura
Jay Shendure
David R. Beier
Jan Marino Ramirez
Mark W. Majesky
Kathleen J. Millen
Marc Tollis
Danny E. Miller
Publication Year :
2023
Publisher :
Cold Spring Harbor Laboratory, 2023.

Abstract

There is increasing interest in the African spiny mouse (Acomys cahirinus) as a model organism because of its ability for regeneration of tissue after injury in skin, muscle, and internal organs such as the kidneys. A high-quality reference genome is needed to better understand these regenerative properties at the molecular level. Here, we present an improved reference genome forA. cahirinusgenerated from long Nanopore sequencing reads. We confirm the quality of our annotations using RNA sequencing data from four different tissues. Our genome is of higher contiguity and quality than previously reported genomes from this species and will facilitate ongoing efforts to better understand the regenerative properties of this organism.

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........ccccecf4aa9964387b04c41961eb88f4
Full Text :
https://doi.org/10.1101/2023.04.03.535372