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Prevention of breast cancer in the context of a national breast screening programme
- Source :
- Journal of Internal Medicine. 271:321-330
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- Breast cancer is not only increasing in the west but also particularly rapidly in eastern countries where traditionally the incidence has been low. The rise in incidence is mainly related to changes in reproductive patterns and lifestyle. These trends could potentially be reversed by defining women at greatest risk and offering appropriate preventive measures. A model for this approach was the establishment of Family History Clinics (FHCs), which have resulted in improved survival in younger women at high risk. New predictive models of risk that include reproductive and lifestyle factors, mammographic density and measurement of risk-associated single nucleotide polymorphisms (SNPs) may give more precise information concerning risk and enable better targeting for mammographic screening programmes and of preventive measures. Endocrine prevention using anti-oestrogens and aromatase inhibitors is effective, and observational studies suggest lifestyle modification may also be effective. However, referral to FHCs is opportunistic and predominantly includes younger women. A better approach for identifying older women at risk may be to use national breast screening programmes. Here were described pilot studies to assess whether the routine assessment of breast cancer risk is feasible within a population-based screening programme, whether the feedback and advice on risk-reducing interventions would be welcomed and taken up, and to consider whether the screening interval should be modified according to breast cancer risk.
- Subjects :
- Gerontology
0303 health sciences
medicine.medical_specialty
education.field_of_study
Referral
business.industry
Incidence (epidemiology)
Population
Psychological intervention
Context (language use)
medicine.disease
3. Good health
03 medical and health sciences
0302 clinical medicine
Breast cancer
030220 oncology & carcinogenesis
Family medicine
Internal Medicine
medicine
Observational study
Family history
business
education
030304 developmental biology
Subjects
Details
- ISSN :
- 09546820
- Volume :
- 271
- Database :
- OpenAIRE
- Journal :
- Journal of Internal Medicine
- Accession number :
- edsair.doi...........cccfe3a437deb11a7d11d82854672e27