ChemInform Abstract: Copper(II) Bromide Catalyzed Novel Preparation of Propargylic Ethers and Sulfides by SN1-Type Substitution Between Propargylic Alcohols and Alcohols or Thiols

A general and efficient copper(II) bromide catalyzed substitution reaction of propargylic alcohols with carbon and heteroatom-centered nucleophiles, such as alcohols and thiols, leading to the construction of C-O and C-S bonds has been developed. High product yields were obtained with excellent regioselectivity.