ChemInform Abstract: Synthesis of Spiro Pyrrolobenzothiazole Derivatives via a Three-Component Reaction

A novel three-component reaction involving 2-methylbenzothiazole or 2,5-dimethylbenzothiazole, acetylenic esters and 1,3-dicarbonyl compounds such as (1,3-dimethylbarbituric acid or 1,3-indanedione) leading to the synthesis of spiro pyrrolobenzothiazole derivatives. The reactions proceeded smoothly at room temperature without using any catalyst. This method is very useful to functionalize benzothiazole derivatives in a one-pot operation. The structures of the synthesized compounds have been characterized by spectral studies.