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ChemInform Abstract: Electrochemical Fluorination of (N,N-Dialkylamino)alcohols
- Source :
- ChemInform. 30
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- Series of amino alcohols including 2-( N,N -dialkylamino)ethanols, 3-( N,N -dimethylamino)propanol and 4-( N,N -dimethylamino)butanol were subjected to electrochemical fluorination. In the case of 2-( N,N -dialkylamino)ethanols, the F -(2- N,N -dialkylamino)acetyl fluorides were obtained in fair to good yields. Yields of each target compound were strongly dependent on the kind of the dialkylamino group. Cyclic amines having an N -(2-hydroxylethyl) group afforded the corresponding F -[ N -( c -alkylamino)-substituted acetyl fluorides]. Their yields were generally better than those of acyclic analogs. Several 2-( N,N -dialkylamino)ethanols and 3-( N,N -dimethylamino)propanol were converted into the corresponding trimethylsilylethers, aminoalkyl methyl carbonates and bis-aminoalkyl carbonate, respectively, and they were subjected to fluorination for a comparison of the yield with that obtained from that of the parent aminoalcohol.
Details
- ISSN :
- 15222667 and 09317597
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........ce38deede6e4ae38feee0f830803307d