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Single Administration of α-Glucosidase Inhibitors on Endothelial Function and Incretin Secretion in Diabetic Patients With Coronary Artery Disease
- Source :
- Circulation Journal. 74:1471-1478
- Publication Year :
- 2010
- Publisher :
- Japanese Circulation Society, 2010.
-
Abstract
- Background: Post-prandial hyperglycemia, hyperlipidemia, and endothelial dysfunction play an important role in the pathogenesis of atherosclerosis. Improvement in post-prandial hyperglycemia on α-glucosidase inhibitors (α-GIs) is associated with a risk reduction of cardiovascular diseases, but the post-prandial effects of α-GIs on endothelial function and incretin secretion in type 2 diabetic patients with coronary artery disease (CAD) remain unclear. Methods and Results: The post-prandial effects of a single administration of miglitol and voglibose on endothelial function and changing levels of glucose, insulin, lipids, glucagon-like peptide (GLP)-1, and gastric inhibitory polypeptide (GIP) were compared after a standard meal loading in 11 diabetic patients with CAD, using a placebo-controlled cross-over design. The changing levels of glucose, insulin and triglycerides at 60 min were significantly lower in the miglitol group than in the voglibose and placebo groups (all P
- Subjects :
- Alpha-glucosidase inhibitor
medicine.medical_specialty
business.industry
medicine.drug_class
Insulin
medicine.medical_treatment
Miglitol
digestive, oral, and skin physiology
Incretin
General Medicine
medicine.disease
Endocrinology
Diabetes mellitus
Internal medicine
Voglibose
Medicine
Endothelial dysfunction
Cardiology and Cardiovascular Medicine
business
Reactive hyperemia
medicine.drug
Subjects
Details
- ISSN :
- 13474820 and 13469843
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- Circulation Journal
- Accession number :
- edsair.doi...........ceaec58176c171c913218efc477112cb